The earliest stage of cognitive impairment in transition from normal aging to Alzheimer disease is marked by prominent RNA oxidation in vulnerable neurons.
نویسندگان
چکیده
Although neuronal RNA oxidation is a prominent and established feature in age-associated neurodegenerative disorders such as Alzheimer disease (AD), oxidative damage to neuronal RNA in aging and in the transitional stages from normal elderly to the onset of AD has not been fully examined. In this study, we used an in situ approachto identify an oxidized RNA nucleoside 8-hydroxyguanosine (8OHG) in the cerebral cortex of 65 individuals without dementia ranging in age from 0.3 to 86 years. We also examined brain samples from 20 elderly who were evaluated for their premortem clinicaldementia rating score and postmortem brain pathologic diagnoses to investigate preclinical AD and mild cognitive impairment. Relative density measurements of 8OHG-immunoreactivity revealed a statistically significant increase in neuronal RNA oxidation during aging in the hippocampus and the temporal neocortex. In subjects with mild cognitive impairment but not preclinical AD, neurons of the temporal cortex showed a higher burden of oxidized RNA compared to age-matched controls. These results indicate that, although neuronal RNA oxidation fundamentally occurs as an age-associated phenomenon, more prominent RNA damage than in normal aging correlates with the onset of cognitive impairment in the prodromal stage of AD.
منابع مشابه
Effect of Mild Cognitive Impairment and Alzheimer Disease on Auditory Steady-State Responses
Introduction: Mild Cognitive Impairment (MCI), a disorder of the elderly people, is difficult to diagnose and often progresses to Alzheimer Disease (AD). Temporal region is one of the initial areas, which gets impaired in the early stage of AD. Therefore, auditory cortical evoked potential could be a valuable neuromarker for detecting MCI and AD. Methods: In this study, the thresholds of...
متن کاملWhite matter lesions are prevalent but differentially related with cognition in aging and early Alzheimer disease.
BACKGROUND White matter lesions (WMLs) are prevalent in nondemented aging and in Alzheimer disease (AD). Their relationship with cognition in the earliest stages of AD is unknown. OBJECTIVE To assess the relationship between WMLs and cognition in nondemented aging and in early-stage AD. DESIGN Cross-sectional study. SETTING Alzheimer Disease Research Center, St Louis, MO. PARTICIPANTS P...
متن کاملComparison of visual evoked potential changes in patients with alzheimer, vascular dementia and minimal cognitive Impairment with healthy people: a case-control study
Background: Alzheimer dementia as the most common cause of dementia is a chronic, progressive, irreversible and incurable disease. The second most common cause of dementia after Alzheimer is vascular dementia. One of the systems involved in dementia is the visuospatial system and visual evoked potential (VEP) can be one of the diagnostic methods for this disease. Therefore, the present study ai...
متن کاملEffect of Amnesia Mild Cognitive Impairment and Alzheimer’s Diseaseon Recognition Memory of Elderly Peoplein Shiraz Verbal Learning Test: Differences in Recognition Discriminability and Response Bias
Background: Most studies have investigated the effect of brain pathological aging on information recall and recognition memory performance of patients (by using a yes/no procedure), and for this reason, provide a partial picture of memory deficits and other factors involved in recognition memory such as discriminability and response bias are not considered. In this regard, the aim of present st...
متن کاملP 81: Omega-3 Fatty Acid and Oxylipins in Management of Alzheimer Disease
Neurodegenerative disease are characterized by the progressive loss of neurons from specific origins of the CNS .Alzheimer disease (AD) is a neurodegenerative disorder which affect brain regains that control memory and ability to learn. It is estimated that 27 million people are affected word wide and this number is expected to triple by 2050 due to increase of the population life expectancy. A...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Journal of neuropathology and experimental neurology
دوره 71 3 شماره
صفحات -
تاریخ انتشار 2012